I like having everything on the computer nice and neat. Therefore, I've color coded every icon on my desktop. Blue for essential/important software, orange for tools/utilities, gray for Steam bought games, red for non-steam games/interactive media. If you notice, each category string starts at a corner and then swirls around the screen to keep the background as visible as possible.
With each screen having a one of my favorites fictional/digital characters in background. GLaDOS, which is a screenshot I took directly for Portal 2, and Master Tigress, whom was drawn by a artist that goes under the name HYH Lion.