I've been on 100mg of Zoloft for a few months now, and for me it seems to be doing a decent job. I do feel pretty tired and fatigued most days, and I have also experienced weight gain, occasional gastrointestinal problems, extremely vivid dreams, and more sweating than usual (and feeling warm/hot a lot). But for me, it's worth it to not be depressed and suicidal anymore.
Whether Zoloft is right for you really depends on how Zoloft works with your body and what side effects you're willing to put up with in exchange for the benefits.