Not really. I have work colleagues, but that's not the same, it's not really "talking" to them, it's just talking about work or occasionally chatting about random stuff. Nothing meaningful.
Online-wise, just my parents on MSN and people on these random forums I join. Though even on the forums I've been a member of for years I still don't really "know" many people or am friends with any of them. I'm just pretty crap at making friends >.>