Hi, I took three capsules twice a day(six capsules a day)on an empty stomache when I first started. After it kicked in, I slowly worked myself down to one capsule a day. If it helps you just experiment with it until you find the best way to take it.
I am also on an anti-depressant, so for me it is o.k. to combine herbs and other remedies with medicine. But everyone is different, so be aware of what you are taking and how it makes you feel.
My best advice for those seeking relief from s.a., is to try everything out there. It can definitely get expensive, but for me it has been worth it. Through a combination of noni juice, colostrum, lemon balm, and an anti-depressant, I have overcome my s.a. I hope you all do too.