I tried the Drionic ionto device a long time ago, maybe 2002ish, and didn't have any success with it at all. I found it painful, time consuming, and no matter how much I stuck to the regimen, ineffective. That experience turned me off from iontophoresis for a long time, but I'm giving it another shot now based on some positive testimonials I've read more recently online for some of the newer devices.
What brand of iontophoresis device do you have? Are you able to control the voltage on it? I have the Hidrex PSP 1000, which allows a lot of customization. So far, I've been doing 15 minutes/day on my hands (90% pulsed current, 20 volts) and my feet (70% pulsed currents, 30 volts).
I have just been using it for five days, so definitely too early to tell. The first day, I took my glyco as usual, and was blown away by how extremely dry I felt all over--hands almost didn't sweat the whole day--so I stopped taking the glyco for the next two days. It was my first time not being on glyco for even a day in over a decade. I felt dry for one more day, then woke up sopping wet the next. I'm back to taking glyco as usual for a while longer. Eventually I do want to test whether I can achieve dryness without it at all (just with ionto), but for now, it still seems necessary.
It seems like a lot of people have success with ionto after 3-4 weeks. Some people experience a temporary increase in sweating first, which I seem to be having now. I will keep you posted on my continuing experiences.