I take medications. I have Social Anxiety, PTSD, and pretty severe Depression. I take Zoloft (kinda helps with anxiety, but mostly helps with depression), Wellbutrin (depression), Klonopin (anxiety... I really like this pill but it can be habit forming and it can give off the same effects of alcohol - slurred speech, confusion bad short-term memory, dizziness - so you have to use it carefully), the beta-blocker Propranolol (social anxiety.. I just started taking this, and it works really wonderfully. You still have thoughts of anxiety, etc, but the Propranolol blocks some physical symptoms. You may feel not-so-great, but you don't sweat so much, etc. I know a girl who plays violin professionally and is terrified of being on stage - she takes a Propranolol 15 mins before performance time and she's fine when she goes on stage!), I also have mild ADD so I take Adderall... Oddly, this boosts my self-esteem I've found, but it sort of makes your heart beat more rapidly, etc, but then, you have more motivation to get out, do things, strike up conversations, learn and persue interests... Note, I only take the Zoloft and Wellbutrin daily, the other drugs are "as needed". My anxiety is incredibly severe (as I'm sure others is) so I have Ambien (as needed) to help me sleep. Drinking with these meds in your system is a no-no, you'll black out after one shot. It took me yeeears to get this concoction right, and I still think there's room for improvement. It's very embarassing lugging around so many pills when I go places (I travel a lot for my nonprofit work), but they work for me. Everyone's different. I'd like to also know what others find helpful... the Klonopin is a little risky for me so I'd like to eventually get off of that since I'm only 21 and I think I'm justified to a few drinks here and there like any "normal" person my age.