Whats everyones take on 5-HT2C antagonists?

[DillJenkins]

I hear they decrease anxiety with antagonism.

Prozac can have 5-HT2C antagonism I hear.

http://www.pnas.org/content/94/5/2036.full.pdf

 

[Noca]

Too much chemistry that I know nothing about. Is there any other meds besides Prozac that are 5-HT2C antagonists?

 

[DillJenkins]

5-HT2C receptor - Wikipedia, the free encyclopedia

This is the list. I see that Mirtazapine is on the list as well.

I hear that psychedelic drugs are agonists at this receptor. This could potentially be the mechanism behind their anxiogenic action.

I like pharmacology because its easy. You simply agonize and antagonize receptors and observe the behavior change. Sometimes there are things like downstream effects that you must also learn. Like a change in the 5-HT2C receptor will affect dopamine release in other areas of the brain.