EDIT: Nevermind, calls for 1g of glyco, i thought it was 1mg.
I suffer from facial hyperhidrosis primarily, but it can extend to my back, arms, trunk when it gets to its extreme cases. I found out about glycopyrrolate a few weeks back and I noticed that the cost, at a dose of 3mg/day orally, would be pretty high for a student.
I also noticed that the oral form has more side effects than the topical form. Since I only really need a relief for my face, the topical version really appeals to me.
Since I can't get a prescription just yet, I was looking for a way to cut down the costs.
I found the formula for topical glycopyrrolate online, for a 1% solution.
Preparation of 100 mL Solution of 1% Glycopyrrolate
A 1% glycopyrrolate solution was made by dissolving glycopyrrolate powder in the 66.7 mL distilled water and 33.3 mL of 95% ethanol solution.
Take water 66.7 mL
Add 95% ethanol 33.3 mL
Adjust pH to 4.0 (range 3.5 to 4.5) with a few drops of hydrochloric acid
Add 1 gram of glycopyrrolate stir until glycopyrrolate completely dissolved.
To make 2% solution add 2 gram glycopyrrolate instead of 1 gram etc.
The resulting solution of glycopyrrolate contains approximately 31.635% of ethanol. To avoid skin irritation, the pH of the formulation should be close to that of the skin (pH 5.5). For the chosen 66.7%/33.3% distilled water/95% ethanol solution, the pH level was adjusted to 4.0 with hydrochloric acid. The pH of 4.0 was chosen for stability of the solution and to be as close to the pH of the skin (pH 5.5) as possible.
Pouring 30 to 36 mL of said glycopyrrolate solution onto the top pad of a container of 30 rayon/polypropylene pads; and Covering the container with a resealable lid.
Topical glycopyrrolate product - US Patent 7060289 Description
Here, 1 gram of glycopyrrolate would last about a month if one pad was used a day at 1% solution. If I understand correctly, muriatic acid can be substituted in where hydrochloric acid is needed (30% hcl solution)? After that, its just a point of getting some non-cotton cosmetic pads, resealable container, 95% ethanol (which I believe is available at liquor stores) and some distilled water.
I would be using Avert pills crushed into a fine powder.
Seems to me like an excellent way to cut costs as long as you do everything correctly and with care. Input?
Thanks
I suffer from facial hyperhidrosis primarily, but it can extend to my back, arms, trunk when it gets to its extreme cases. I found out about glycopyrrolate a few weeks back and I noticed that the cost, at a dose of 3mg/day orally, would be pretty high for a student.
I also noticed that the oral form has more side effects than the topical form. Since I only really need a relief for my face, the topical version really appeals to me.
Since I can't get a prescription just yet, I was looking for a way to cut down the costs.
I found the formula for topical glycopyrrolate online, for a 1% solution.
Preparation of 100 mL Solution of 1% Glycopyrrolate
A 1% glycopyrrolate solution was made by dissolving glycopyrrolate powder in the 66.7 mL distilled water and 33.3 mL of 95% ethanol solution.
Take water 66.7 mL
Add 95% ethanol 33.3 mL
Adjust pH to 4.0 (range 3.5 to 4.5) with a few drops of hydrochloric acid
Add 1 gram of glycopyrrolate stir until glycopyrrolate completely dissolved.
To make 2% solution add 2 gram glycopyrrolate instead of 1 gram etc.
The resulting solution of glycopyrrolate contains approximately 31.635% of ethanol. To avoid skin irritation, the pH of the formulation should be close to that of the skin (pH 5.5). For the chosen 66.7%/33.3% distilled water/95% ethanol solution, the pH level was adjusted to 4.0 with hydrochloric acid. The pH of 4.0 was chosen for stability of the solution and to be as close to the pH of the skin (pH 5.5) as possible.
Pouring 30 to 36 mL of said glycopyrrolate solution onto the top pad of a container of 30 rayon/polypropylene pads; and Covering the container with a resealable lid.
Topical glycopyrrolate product - US Patent 7060289 Description
Here, 1 gram of glycopyrrolate would last about a month if one pad was used a day at 1% solution. If I understand correctly, muriatic acid can be substituted in where hydrochloric acid is needed (30% hcl solution)? After that, its just a point of getting some non-cotton cosmetic pads, resealable container, 95% ethanol (which I believe is available at liquor stores) and some distilled water.
I would be using Avert pills crushed into a fine powder.
Seems to me like an excellent way to cut costs as long as you do everything correctly and with care. Input?
Thanks
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