I'm currently on 300 mg. of effexor and i noticed that my anxiety has gotten better. I started off taking 150 and slowly my psychiatrist moved it up. I wasn't too happy about this decision either...but i more or less did whatever the doctor told me....because i was so miserable and full of anxiety before i started taking medication...i was willing to do anything. I have noticed on a few occasions though...that if i have to refill a script and i miss like a day and a half...i start to feel really weird...i think there is a small withdrawal from it. I hate feeling like i have to rely on medication...but sometimes when you feel so isolated and stuck in your own head thinking all day...and not being able to interact with people...you start thinking...maybe i should give this shit a try....but anyway...good luck..... :?