I found this interesting set of postings from Dermatologists' discussions on HH that I thought I should share. The most informative one I thought was this:
"The first order of business is to define the etiology of the
generalized hyperhidrosis. I assembled the following list for your
perusal:
acromegally (especially due to an intrasellar tumor in
young people), thyrotoxicosis, ethanolism, chronic infection, collagen
vascular disease, sarcoidosis, and finally pheochromocytoma. The
latter is especially important to exclude in light of my therapeutice
recommendation, phenoxybenzamine, 10 mg/day. This alpha adrenergic
antagonist is useful in generalized hyperhidrosis. However, it may
induce a hypertensive crisis if used in the setting of
pheochromocytoma.
Anticholinergic, muscarinic antagonists, propantheline bromide, 15 mg
p.o. TID and methantheline bromide may also be useful, but their use
is limited by side effects. I hope that this helps.
Rhett Drugge, M.D."
Link: http://dermatology.cdlib.org/rxderm-archives/hyperhidrosis
I thought it was interesting that he lists several causes of generalized HH that I hadn't known about - namely pheochromocytoma and the intrasellar tumor in young people. Also, has anyone tried phonoxybenzamine?
"The first order of business is to define the etiology of the
generalized hyperhidrosis. I assembled the following list for your
perusal:
acromegally (especially due to an intrasellar tumor in
young people), thyrotoxicosis, ethanolism, chronic infection, collagen
vascular disease, sarcoidosis, and finally pheochromocytoma. The
latter is especially important to exclude in light of my therapeutice
recommendation, phenoxybenzamine, 10 mg/day. This alpha adrenergic
antagonist is useful in generalized hyperhidrosis. However, it may
induce a hypertensive crisis if used in the setting of
pheochromocytoma.
Anticholinergic, muscarinic antagonists, propantheline bromide, 15 mg
p.o. TID and methantheline bromide may also be useful, but their use
is limited by side effects. I hope that this helps.
Rhett Drugge, M.D."
Link: http://dermatology.cdlib.org/rxderm-archives/hyperhidrosis
I thought it was interesting that he lists several causes of generalized HH that I hadn't known about - namely pheochromocytoma and the intrasellar tumor in young people. Also, has anyone tried phonoxybenzamine?