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Old 06-01-2009
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Generic name: Hyoscyamine - extended release tabs will last you 12 hours. Take it twice a day.

Brand name: Symax Duo Tabs - this has combined extended with rapid release, Levbid, Levsin, etc.

Technically this is an antispasmodic, but it also works by blocking signals in the autonomic nervous system. It is the best drug for hyperhidrosis, as well as some of the other issues that come with hyperhidorsis, IBS, GI issues, etc.

Before this I tried Robinul, which sucks because I had to take it every few hours and it caused horrible dry mouth, headaches, and other side effects.

It took about 2-3 weeks for me to get over the side effects of Hyoscyamine, but once you do the results are impressive. I've been on some form of this drug for the last 8-years and it works better than anything else on the market, and has stood the test of time when many other drugs have let me down.
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Hello there, this sounds promising. Can i ask what kind of HH you have, and if its constant or anxiety related?

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Old 06-01-2009
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I had sweaty hands, feet, and under arms.

I then had ETS surgery, now I have a sweaty chest, back, thighs, legs, feet, and under arms. With my Symax Duo Tabs I sweat 20-60% of the time, without the meds I'm about 60-90% of the time.

Because of the surgery my left hand still gets clammy, but doesn't drip anymore, and my right hand is completely dry.

My face only sweats now when I eat something that can set it off. Otherwise it doesn't seem to be temperature related.

Last edited by applextrent; 10-28-2010 at 04:17 AM.
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Old 06-01-2009
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That's great that you have found some relief. I have used a similar med in the past: 'belladonna alkaloids w pb tablets'...related to atropine, which certainly dried up my bodily secretions! However, the cost/benefit ratio started to catch up to me. I was feeling really dry and comfortable for about two weeks. However, I was also experiencing side affects like drowsiness, brain fog and slurred speech. After about two weeks, the anti-sweating affects became less effective (but still better than nothing), though the side affects remained. I ditched it this past winter all together.

Perhaps I will give Hyoscyamine a try.
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Old 06-02-2009
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wat are the side effects of this drug? Also, do you build tolerance in the long run?
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Old 06-02-2009
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Side effects include dry mouth and throat, eye discomfort, blurred vision, restlessness, dizziness, flushing, and in some cases faintness. Hyoscyamine - Wikipedia, the free encyclopedia

I've pretty much gotten over the side effects entirely, it took about 2-3 weeks before they went away and that was almost 8 years ago.

The only side effect I still get is the dry mouth, and I just make sure to have water, and mints. I also use a saline nasal spray every day as it helps clear up congestion and prevent pressure in the sinus cavities. On a side note since I've been doing this daily I almost never get colds or the flu anymore as well. It's literally just salt water, you can find it at your local pharmacy next to all the nasal sprays, make sure to buy just saline solution without any of those drugs they try and put in nasal sprays, the saline works just fine without the drugs.

There are a variety of brands, generics, and styles of this drug so you can usually find one that keeps your sweat at bay without as many side effects.

I prefer Symax Duotabs personally, but there is a generic version available, and there are varying dosages. So you could even potentially ween yourself up to a higher dose if you are worried about side effects.
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Old 06-02-2009
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Does your sweat completely go away when on the drug?
You said it lasted 12 hours?! This is pleasing...have you noticed that its effect is cut short when you eat close to when you took the pill? Just curios to see...
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Old 06-03-2009
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Too much activity, and other environmental factors play a role, and can make me sweat even on the drug, but yes it can and does provide dry periods lasting for several hours where I won't sweat at all. It also reduces the overall sweating when I do sweat.

As I said, this is one of the most effective medications I've found, and you only take it twice a day.

Out of all the drugs I've ever taken or done, this is by far the only one I simply cannot live without for it also keeps my IBS in check.
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Old 06-03-2009
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I was reading the side effects of this drug in the link above and it doesn't sound like it's meant to be taken everyday.

Side effects

Side effects include dry mouth and throat, eye pain, blurred vision, restlessness, dizziness, arrythmia, flushing, faintness. An overdose will cause headache, nausea, vomiting and CNS symptoms including disorientation, hallucinations, euphoria, sexual arousal, short-term memory loss and possible coma in extreme cases.
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Old 06-04-2009
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So if I was to take it in the morning before school, do you think I would stay dry all school day?

That is really my main problem with hyperhidrosis, it makes easy things like school so much more complicated than it should be,
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Old 06-04-2009
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It's an anticholinergic, so it's workings are the same as glyco/oxubutynin/probantheline etc.

However, of course there can be some difference in tolerance among these drugs. Also, some cross the brain/blood barrier and some don't, some are water insoluble and some aren't...etc.

Since you have used both glyco (which is generally said to be the best tolerated while still effective for HH) and this one and found this one better, that's good info...

Hopefully something better than anticholinergics will come along eventually, but for the time being, it seems these are the only meds that has some positive effects.
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Old 06-05-2009
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Worth a try?
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Old 05-28-2012
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hi,
please can you let me know where you get this drug from it sounds promising. i have been taking avert for a few weeks and it seems to do something, but would like to try this as well.
please can you send me the link to where it can be purchased?
many thanks
dan
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Old 05-28-2012
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Quote:
Originally Posted by g35 View Post
I was reading the side effects of this drug in the link above and it doesn't sound like it's meant to be taken everyday.

Side effects

Side effects include dry mouth and throat, eye pain, blurred vision, restlessness, dizziness, arrythmia, flushing, faintness. An overdose will cause headache, nausea, vomiting and CNS symptoms including disorientation, hallucinations, euphoria, sexual arousal, short-term memory loss and possible coma in extreme cases.
A coma? X_x

I'll pass.
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Old 07-31-2013
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any updates on hyoscyamine such as availability or has anyone else had good results? im interested in trying it, avert and ditropan dont work for me unless i take about double the recommended limit daily in which case ill feel like a space cadet on mars from the side effects, and even then ill only be dry maybe 3 hours after which Ill be drenched directly after. maybe hyo. (levsin) will work better for me?
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Old 07-31-2013
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Quote:
Originally Posted by wannabedry View Post
any updates on hyoscyamine such as availability or has anyone else had good results? im interested in trying it, avert and ditropan dont work for me unless i take about double the recommended limit daily in which case ill feel like a space cadet on mars from the side effects, and even then ill only be dry maybe 3 hours after which Ill be drenched directly after. maybe hyo. (levsin) will work better for me?
I would suggest that if you can't tolerate avert (which does cross BBB), then you certainly won't be able to tolerate Hyocyamine which does. Research also suggests it lowers serotonin, which will affect mood. Glyo is notoriously poor at gut absorption, therefore it is suggestible to take it on a completely empty stomach with piperine extract to increase effectiveness.
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