I'm confident that Botox can be delivered iontophoretically, but getting it to the stage where it is practical in a clinical setting is the major hurdle. We tried soaking nylon and cotton gloves in Botox solution after pre-blocking to prevent non-specific protein binding of Botox to the gloves, and then treating on standard ionto.units, but that was'nt effective. We have tried Iomed gel sponge delivery pads also with little success. We think binding of Botox to the gel may be a problem as it does appear to preferentially bind to whatever medium introduced as a means of keeping the Botox solution in contact with the skin. The small resevoir worked as it involved solution only and you only have 5mls or so to work with. What kind of iontophoresis device do you have?
Regards
Gina Kavanagh
