new possible phobia medication
- Thread starter MarCPatt
- Start date
Anonymous
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Antibiotics
D-Cycloserine
C3H6N2O2
MW 102.1
Interferes with bacterial cell wall synthesis by competing with D-Alanine for incorporation into the cell wall. Active against most mycobacteria with some activity against gram negative bacteria. --Research Products International
NEW ORLEANS, LA -- November 12, 2003 -- D-cycloserine, an old standby in tuberculosis therapy, may find new use in boosting the effectiveness of psychotherapy, according to early work reported here November 10th at the Society for Neuroscience 33rd Annual Meeting....
...Emory University investigators used virtual reality to simulate a ride in a glass elevator for people afraid of heights. They tested D-cycloserine in a suboptimal set of two sessions of this phobia-extinction therapy. More sessions are usually required to extinguish the phobia. Anxiety was rated 1 week later, and then 3 months later.
Thirty patients participated, with 10 receiving placebo, and 10 each taking 1 of 2 doses of D-cycloserine. Not much difference was demonstrated between the high-dose group and the low-dose group, and in fact, the higher dose, 100 mg, used for tuberculosis, was slightly poorer at aiding the therapy than the 10-mg dose, Dr. Davis said.
Anxiety was rated with a Subjective Units of Discomfort scale, which showed a 10% to 20% improvement for placebo-treated patients after 2 sessions, but a 50% to 60% improvement when the agent was taken before the sessions. The difference was statistically significant, Dr. Davis said....
Dr. Davis said the idea would be to "take the drug before you go to your therapist. That gets around the tolerance that often happens in the brain [with many psychoactive drugs]."
---from http://www.pslgroup.com/dg/23e54e.htm
D-Cycloserine
C3H6N2O2
MW 102.1
Interferes with bacterial cell wall synthesis by competing with D-Alanine for incorporation into the cell wall. Active against most mycobacteria with some activity against gram negative bacteria. --Research Products International
NEW ORLEANS, LA -- November 12, 2003 -- D-cycloserine, an old standby in tuberculosis therapy, may find new use in boosting the effectiveness of psychotherapy, according to early work reported here November 10th at the Society for Neuroscience 33rd Annual Meeting....
...Emory University investigators used virtual reality to simulate a ride in a glass elevator for people afraid of heights. They tested D-cycloserine in a suboptimal set of two sessions of this phobia-extinction therapy. More sessions are usually required to extinguish the phobia. Anxiety was rated 1 week later, and then 3 months later.
Thirty patients participated, with 10 receiving placebo, and 10 each taking 1 of 2 doses of D-cycloserine. Not much difference was demonstrated between the high-dose group and the low-dose group, and in fact, the higher dose, 100 mg, used for tuberculosis, was slightly poorer at aiding the therapy than the 10-mg dose, Dr. Davis said.
Anxiety was rated with a Subjective Units of Discomfort scale, which showed a 10% to 20% improvement for placebo-treated patients after 2 sessions, but a 50% to 60% improvement when the agent was taken before the sessions. The difference was statistically significant, Dr. Davis said....
Dr. Davis said the idea would be to "take the drug before you go to your therapist. That gets around the tolerance that often happens in the brain [with many psychoactive drugs]."
---from http://www.pslgroup.com/dg/23e54e.htm
